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Differential effects of CDDO-Im and hemin on the expression of HO-1, SPIC, and NQO1 genes. Thioglycolate-induced peritoneal macrophages were isolated from HO-1DsRed/+ and Nrf2−/−::HO-1DsRed/+ mice, and the macrophages were treated with 10 nM CDDO-Im (A, C, and E) or 30 μM hemin (B, D, and F) for 6 h. Relative expressions of HO-1 (A and B), SPIC (C and D), and NQO1 (E and F) of HO-1DsRed/+ and Nrf2−/−::HO-1DsRed/+ macrophages were examined. ***, P < 0.001.
