Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pol κ controls the Chk1 pool independently of its DNA synthesis activity. Quantification of Chk1 immunostaining in HCT116 (A) and RKO (B) cells cotransfected with the indicated siRNAs and with a control vector expressing GFP-empty or GFP-Polκ-Dead. At 48 h after transfection, the fluorescence intensity of Chk1 was quantified in each nucleus. Medians with 25% and 75% interquartile ranges are represented. ****, P < 0.0001; Mann-Whitney test.
