FIG 1.

Study design and cohorts. Schematic showing number of individuals within the Arivale wellness intervention cohort who match our selection criteria for data completeness and “weight loss” and “no weight loss” groups (A). In panels A to C, individuals in the “weight loss” group lost >1% of body weight per month during the program whereas the “no weight loss” group maintained a stable weight, changing less than 0.1%. Distribution of relative weight change for the 239 candidate individuals, with blue area showing individuals who lost >1% of their body weight per month (n = 48) and red area showing individuals who showed no change in weight (n = 57) over the same intervention period (B). Baseline and follow-up BMI values (points from the same individual connected by lines colored by weight loss group: cyan lines denote “weight loss” and red lines denote “no weight loss”) for our “weight loss” and “no weight loss” cohorts (n = 105) (C). Green dots in panel C denote individuals with additional proteomic and metagenomic data (n = 25).