FIG 3.

pdu and cobalamin operon abundance in healthy oral metagenomes. (A) MultiGeneBlast comparison between the pdu operon found in Streptococcus sp. F0442 by gutSMASH and the characterized one from Lactobacillus reuteri (AP007281). (B) Read coverage of five randomly chosen healthy metagenomes along the gutSMASH-predicted pdu gene cluster. The coverage graphs, which were plotted using the Sushi R package (version 3.5.1) (45), show that some samples (3 and 4) contain reads that cover the whole gene cluster, while in other samples, reads hardly cover the cluster (1 and 2) or cover only part of it (5).