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. Author manuscript; available in PMC: 2023 Sep 26.
Published in final edited form as: J Med Chem. 2021 Oct 19;65(4):2940–2955. doi: 10.1021/acs.jmedchem.1c01307

Figure 2. PLpro inhibition and binding affinity.

Figure 2.

A) Chemical structures and dose response of the most potent PLpro inhibitors in enzymatic assays: GRL0617 (1), ZN-2-184 (5), ZN-3-80 (65), XR8-24 (73), XR8-23 (72). B) Comparison of KD measured by SPR with IC50 measured in enzyme inhibition assay. Also see Figure S1.