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. Author manuscript; available in PMC: 2023 Sep 26.
Published in final edited form as: J Med Chem. 2021 Oct 19;65(4):2940–2955. doi: 10.1021/acs.jmedchem.1c01307

Scheme 1.

Scheme 1.

Reagents and conditions: I. (Amines, aldehydes or ketones), HOAc, NaBH3CN, MeOH; II. (Amines or carboxylic acids), HATU, DMAP, DMF, rt; III. HCl (4M in dioxane), DCM; IV. XPhos Pd G2, K3PO4, DMF/EtOH/H2O, 95 °C.