Table 3.

Studies of topical doxepin

Study	Year	Setting/design	Inclusion criteria	Patient number	Intervention	Control	Outcomes	Follow-up
Kwa et al33	2020	Multicenter cross-over RCT	Healed burn, itch VAS≥3, pruritic area <10%	27	Doxepin cream	Placebo cream	Pruritus VAS BIQ at week 2 and week 5	5 weeks
Kwa et al32	2019	Multicenter RCT	Healed burn, itch VAS≥3	31	Doxepin cream and placebo tablet	Placebo cream and antihistamine tablet	Pruritus VAS BIQ QOL SF-36 Somnolence Erythema	12 weeks
Demling et al34	2003	Single center RCT	Healed, <35% TBSA partial thickness burn, pruritic area <20%	31	Doxepin	Standard care	Pruritus VAS Erythema (Vancouver Scar Scale)	12 weeks
Demling et al31	2002	Single center RCT	Healed burn, pruritic area <15%	41	Doxepin	Standard care	Pruritus VAS Erythema (Vancouver Scar Scale)	12 weeks

BIQ, Burn Itch Questionnaire; QOL SF-36, Quality of Life Short Form-36 questionnaire; VAS, Visual Analog Scale.