Table 2: Impact of OA on human immune cell subsets in adults and children.
Up arrows (↑) indicate enriched populations, down arrows (↓) indicate less prevalent populations, sideways arrows (→) indicate no significant difference measured for each comparison specified in the column header. Italicized entries indicate results from adult studies and non-italicized entries are from pediatric studies. OA = obese asthma, A= asthma (non-obese), O= obese (non-asthma), HC= healthy control (non-asthma, non-obese).
| Human Obese Asthma | |||||
|---|---|---|---|---|---|
| Results | OA vs HC | OA vs A | OA vs O | ||
| Immune Function | Innate Immune Cells | Eosinophils |
↑(143) submucosal
→(143) sputum and blood |
↑(161) | |
| Monocytes | CD14+CD16- ↓(141) CD14dimCD16+ ↓(141) |
||||
| Adaptive Immune Cells | CD4 T cells | →(128) | →(162) | →(162) | |
|
→(163)
|
→(155,163) | →(163) | |||
| Th1 | ↑(140,141) | ↑(140,141) | |||
| Th2 | ↓(140,141) | ||||
| Treg | ↑(163) | ↑(163) | ↑(163) | ||
| IgE | ↑(161) | ||||
| Type 2 cytokines (serum) | IL-4 | →(140) |
→(140,142,164) ↓(165) |
→(140,142,166) |
|
| IL-5 | →(140) | →(140,164) ↑(143) sputum |
→(140) | ||
| IL-13 | →(140) | ↓(140,164) | →(140) |
||
| Type 1 cytokines (serum) | IFN-g | ↑(165) →(140,141) ↓(142) |
↑(165) →(140–142,164) |
→(140–142) |
|
| TNF-α | ↑(140) →(127) |
→(140) | →(140) | ||
| IL-6 | ↑(140) |
→(140,164) | →(140) | ||
| IL-8 | ↑(164) | ||||
| Adipokines | Leptin | ↑(165) →(140,166) |
↑(140,141,165–167) ↑(166) |
→(140,166) | |
| Adiponectin | →(161) | →(161) | →(161) | ||
| Pulmonary Function | FEV 1 /FVC | →(161) | ↓(140) →(50,156,162,165) |
↓(140) →(161) |
|