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. 2021 Oct 12;9:746932. doi: 10.3389/fcell.2021.746932

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Copyright © 2021 Shen, Liu, Lv and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Correlation analysis of CLEC5A expression and immune cell components in the TME of OC (TCGA-OV dataset). (B) Correlation analysis between the expression of CLEC5A and the infiltration of M1 and M2 macrophages in TME of OC. (C) Correlation analysis of CLEC5A expression and immune checkpoint gene. (D) When the M2 macrophages were co-culture with OC cell line HEY overexpressing CLEC5A, the M2 polarization level of macrophages increased. (E) After overexpression of CLEC5A in M2 macrophages, the M2 polarization level increased. (F) The expression of immune checkpoint genes PD-L1, PD-L1, CD47, TIM3, and LAG3 increased in OC cell line HEY overexpressing CLEC5A. ****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05; ns, no significance.