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. 2021 Oct 12;11:748730. doi: 10.3389/fonc.2021.748730

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Copyright © 2021 Zhang, Li, Du, Li, Shi, Chen, Zhao, Wang and Pan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adipocytic GS overexpression via altered histone methylation induces chemoresistance to 5FU in peritoneal carcinomatosis of colorectal cancer metastasis. Adipocyte-derived glutamine (Gln) promotes resistance to 5FU chemotherapy via inducing mTOR activation in CRC cells. Adipocyte-derived Gln production is increased by Gln synthetase (GS) upregulation, which is regulated by altered histone methylation. Loss of H3k4me2 increases GS expression in adipose cells.