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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Regul Toxicol Pharmacol. 2021 Aug 10;125:105026. doi: 10.1016/j.yrtph.2021.105026

Fig. 2.

Fig. 2.

Points of departure (PoDs) plotted against predicted plasma exposure for coumarin case study (face cream exposure). PoDs expressed as free concentration in assay/plasma. Red line = Plasma Cmax free (μM); pink band = uncertainty band in plasma level prediction. 1 = IL1β+TNFα+IFNγ; 2 = IL1β+TNFα+IFNγ+TGFβ. BERs calculated to be between 2500 and 38000.