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. Author manuscript; available in PMC: 2021 Oct 26.
Published in final edited form as: Atlas Genet Cytogenet Oncol Haematol. 2012 Dec;2013(5):333–336. doi: 10.4267/2042/49701

Schematic structure of the HACE1 protein.

Schematic structure of the HACE1 protein.

HACE1 contains six ankyrin repeats at the N terminus and a HECT domain at the C terminus. A cysteine residue essential for the ubiquitin ligase activity is at position 876.