Figure 1.

Illustration of photothermal intracellular delivery enabled by localized surface plasmon resonance (LSPR) of gold nanodisks excited by a nanosecond laser. After cell seeding, the laser was rastered over cells seeded onto the nanostructures and cultured in a medium containing membrane impermeable biomolecules. Upon irradiation, the gold plasmonic structures heat up rapidly and generate cavitation bubbles, which facilitate the delivery of the biomolecular cargo into targeted cells by creating transient pores along nearby their outer membranes.