TABLE 1.
Baseline Demographics Comparison for CAT+ Cohort
| Plasma/PRBC | Platelet/PRBC | ||||||
|---|---|---|---|---|---|---|---|
| CAT+ | Off-target | On-target | p | Off-target | On-target | p | |
| (n = 524) | (n = 311) | (n = 213) | (n = 408) | (n = 116) | |||
| Age, y | 37 (24–52) | 40 (25–54) | 31 (22–50) | 0.002 | 36 (23–52) | 43 (24–55) | 0.064 |
| Men | 408 (77.9) | 245 (78.8) | 163 (76.5) | 0.615 | 323 (79.2) | 85 (73.3) | 0.222 |
| Penetrating | 191 (36.5) | 106 (34.1) | 85 (39.9) | 0.205 | 148 (36.3) | 43 (37.1) | 1.000 |
| Blunt | 326 (62.2) | 199 (62.0) | 127 (59.6) | 0.358 | 255 (62.5) | 71 (61.2) | 0.885 |
| Other | 7 (1.3) | 6 (1.9) | 1 (0.5) | 0.297 | 5 (1.2) | 2 (1.7) | 1.000 |
| ISS | 29 (17–41) | 27 (17–41) | 29 (19–38) | 0.320 | 29 (17–38) | 29 (18–42) | 0.420 |
| AIS head | 0 (0–3) | 0 (0–3) | 0 (0–3) | 0.464 | 0 (0–3) | 0 (0–4) | 0.013 |
| AIS chest | 3 (0–4) | 3 (0–4) | 3 (0–4) | 0.436 | 3 (0–4) | 3 (0–3) | 0.020 |
| AIS abdomen | 2 (0–4) | 2 (0–4) | 3 (0–4) | 0.508 | 2 (0–4) | 2 (0–4) | 0.820 |
| Systolic BP, mm Hg | 98 (80–122) | 99 (78–123) | 98 (80–120) | 0.925 | 99 (80–122) | 98 (81–123) | 0.507 |
| HR, beats per minute | 111 (89–132) | 110 (89–132) | 112 (89–131) | 0.644 | 113 (96–98) | 105 (86–123) | 0.097 |
| Temperature, °C | 35.0 (35.6–36.6) | 36.1 (35.4–36.5) | 36.1 (35.6–36.7) | 0.353 | 36.1 (35.6–36.6) | 35.9 (35.6–36.3) | 0.126 |
| GCS | 5 (3–15) | 6 (3–15) | 3 (3–15) | 0.661 | 7 (3–15) | 3 (3–14) | 0.022 |
| pH | 7.2 (7.1–7.3) | 7.2 (7.1–7.3) | 7.2 (7.1–7.3) | 0.637 | 7.2 (7.1–7.3) | 7.3 (7.1–7.3) | 0.008 |
| Base deficit | 1.0 (0.5–3.8) | 0.6 (0.3–5.0) | 1.0 (1.0–2.6) | 0.855 | 1.0 (0.2–2.9) | 2.5 (0.9–4.9) | 0.452 |
| Lactate, mg/dL | 5.2 (3.3–8.8) | 5.3 (3.5–8.1) | 5.1 (3.3–9.2) | 0.864 | 5.3 (3.2–8.3) | 5.1 (3.7–8.9) | 0.983 |
| Hemoglobin, g/dL | 11.1 (9.4–12.7) | 11.1 (9.6–12.7) | 11.2 (9.3–12.8) | 0.940 | 11.4 (9.9–12.8) | 10.1 (8.8–12.0) | 0.001 |
| PTT, s | 30.4 (25.2–38.8) | 28.0 (24.8–35.6) | 32.5 (26.5–41.8) | <0.001 | 30.1 (25.1–36.7) | 33.0 (26.4–41.0) | 0.072 |
| PT, s | 15.9 (14.1–18.7) | 15.0 (12.8–17.7) | 17.3 (15.1–19.9) | <0.001 | 15.6 (14.0–18.4) | 17.4 (14.7–21.2) | 0.004 |
| INR | 1.3 (1.2–1.6) | 1.2 (1.1–1.5) | 1.4 (1.2–1.7) | <0.001 | 1.3 (1.2–1.6) | 1.4 (1.2–1.7) | 0.032 |
| OR intervention | 424 (80.9) | 254 (81.7) | 170 (79.8) | 0.675 | 331 (81.1) | 93 (80.2) | 0.923 |
All values are presented as n (%) or median (IQR).
CAT+, patients requiring more than 3 U of PRBCs within any hour during the first 6 hours.
On-target, patients with a 6-hour ratio >0.75 and who spent ≥40% of their time above this threshold.
Off-target, all other patients not meeting on-target criteria.
BP, blood pressure; GCS, Glasgow Coma Scale; HR, heart rate; INR, international normalized ratio; IQR, interquartile range; ISS, Injury Severity Score; PT, prothrombin time; PTT, partial thromboplastin time.