TABLE 2.

Comparison of Transfusion Requirements and Mortality for CAT+ Cohort

		Plasma/PRBC			Platelet/PRBC
	CAT+	Off-target	On-target	p	Off-target	On-target	p
	(n = 524)	(n = 311)	(n = 213)		(n = 408)	(n = 116)
6-h Plasma/PRBC	0.72 (0.47–0.96)	0.50 (0.33–0.67)	1.00 (0.86–1.04)	<0.001	0.67 (0.40–0.90)	0.87 (0.67–1.00)	<0.001
6-h Platelet/PRBC	0.29 (0.00–0.80)	0.00 (0.00–0.73)	0.54 (0.00–0.86)	<0.001	0.00 (0.00–0.50)	1.03 (0.86–1.33)	<0.001
6-h Plasma	6 (3–11)	4 (2–8)	8 (6–14)	<0.001	5 (3–10)	8 (4–13)	0.001
6-h Platelet	6 (0–12)	0 (0–6)	6 (0–12)	0.002	0 (0–6)	12 (6–18)	<0.001
6-h PRBC	8 (5–15)	8 (5–16)	8 (5–14)	0.668	8 (5–15)	8 (6–14)	0.697
24-h Plasma/PRBC	0.75 (0.50–1.00)	0.52 (0.33–0.70)	1.00 (0.86–1.22)	<0.001	0.69 (0.44–0.94)	0.83 (0.67–1.10)	<0.001
24-h Platelet/PRBC	0.40 (0.00–0.75)	0.23 (0.00–0.73)	0.55 (0.00–0.86)	<0.001	0.00 (0.00–0.55)	1.00 (0.75–1.24)	<0.001
24-h Plasma	7 (4–14)	5 (2–11)	10 (6–16)	0.504	7 (4–14)	9 (5–16)	0.013
24-h Platelet	6 (0–12)	3 (0–12)	6 (0–12)	<0.001	0 (0–11)	12 (6–18)	<0.001
24-h PRBC	10 (6–18)	9 (6–19)	10 (6–16)	<0.001	10 (6–19)	9 (6–16)	0.851
Died in 3 h	57 (10.9)	49 (15.8)	8 (3.8)	<0.001	54 (13.2)	3 (2.6)	0.002
Died in 6 h	87 (16.6)	68 (21.9)	19 (8.9)	<0.001	79 (19.4)	8 (6.9)	0.002
Died in 24 h	116 (22.1)	83 (26.7)	33 (15.5)	0.003	103 (25.2)	13 (11.2)	0.002
Died in 30 d	169 (32.3)	113 (36.3)	56 (26.3)	0.020	137 (33.6)	32 (27.6)	0.269

All values are n (%) or median (IQR).

CAT+, patients requiring more than 3 U of PRBCs within any hour during the first 6 hours.

On-target, patients with a 6-hour ratio >0.75 and who spent ≥40% of their time above this threshold.

Off-target, all other patients not meeting on-target criteria.

IQR, interquartile range.