Table 2.
HRs of specific SAEs and SAE-related deaths in the age groups following ChA and AD26 vaccination, using BNT vaccination as the baseline reference.
| HR of SAEs mean ± SD (95% CI) |
HR of death events mean ± SD (95% CI) |
|||||||
|---|---|---|---|---|---|---|---|---|
| 18-64 y |
>65 y |
18-64 y |
>65 y |
|||||
| ChA/BNT | AD26/BNT | ChA/BNT | AD26/BNT | ChA/BNT | AD26/BNT | ChA/BNT | AD26/BNT | |
| Cerebral venous thrombosis | 21.59 ± 2.05 (19.44–23.74) |
19.78 ± 1.20 (18.52–21.04) |
5.45 ± 0.70 (4.72–6.18) |
11.34 ± 3.70 (7.46–15.22) |
57.00 ± 5.42 (51.32–62.69) |
35.33 ± 2.14 (33.08–37.58) |
8.17 ± 1.04 (7.08–9.27) |
5.99 ± 1.95 (3.94–8.04) |
| Splanchnic vein thrombosis | 14.58 ± 1.38 (13.13–16.03) |
9.09 ± 0.55 (8.51–9.67) |
7.05 ± 0.90 (6.11–7.99) |
12.52 ± 4.08 (8.24–16.80) |
18.49 ± 1.76 (16.65–20.34) |
7.40 ± 0.45 (6.93–7.87) |
7.99 ± 1.02 (6.92–9.06) |
N.A.a |
| Thromboembolic disease | 10.09 ± 0.96 (9.08–11.10) |
12.85 ± 0.78 (12.03–13.67) |
5.03 ± 0.64 (4.36–5.70) |
7.19 ± 2.34 (4.73–9.65) |
10.58 ± 1.01 (9.53–11.64) |
13.85 ± 0.84 (12.97–14.73) |
4.39 ± 0.56 (3.81–4.98) |
2.32 ± 0.76 (1.52–3.11) |
| Other venous thrombotic events | 9.53 ± 0.91 (8.58–10.48) |
9.17 ± 0.56 (8.58–9.75) |
4.83 ± 0.62 (4.18–5.47) |
4.38 ± 1.43 (2.88–5.88) |
N.A.b | N.A.b | 3.03 ± 0.39 (2.63–3.44) |
38.42 ± 12.52 (25.28–51.56) |
| Nervous system hemorrhage | 11.42 ± 1.09 (10.28–12.56) |
7.98 ± 0.48 (7.47–8.49) |
2.63 ± 0.34 (2.28–2.98) |
4.49 ± 1.46 (2.95–6.02) |
20.62 ± 1.96 (18.56–22.67) |
11.41 ± 0.69 (10.68–12.14) |
1.84 ± 0.23 (1.60–2.09) |
2.22 ± 0.72 (1.46–2.98) |
| Gastrointestinal hemorrhage | 5.63 ± 0.53 (5.07–6.19) |
3.33 ± 0.20 (3.12–3.55) |
2.63 ± 0.33 (2.28–2.98) |
2.81 ± 0.92 (1.85–3.77) |
7.57 ± 0.72 (6.82–8.33) |
5.67 ± 0.34 (5.31–6.03) |
1.73 ± 0.22 (1.50–1.97) |
2.80 ± 0.91 (1.85–3.76) |
| Other hemorrhagic events | 7.06 ± 0.67 (6.36–7.76) |
1.80 ± 0.11 (1.69–1.92) |
3.67 ± 0.47 (3.18–4.16) |
4.67 ± 1.53 (3.07–6.27) |
26.98 ± 2.57 (24.29–29.67) |
23.75 ± 1.45 (22.23–25.27) |
2.02 ± 0.26 (1.75–2.28) |
N.A.a |
| Thrombocytopenia | 19.47 ± 1.85 (17.52–21.41) |
10.48 ± 0.64 (9.81–11.15) |
7.72 ± 0.98 (6.69–8.74) |
4.60 ± 1.50 (3.03–6.18) |
63.37 ± 6.02 (57.05–69.69) |
32.98 ± 2.00 (30.88–35.08) |
7.20 ± 0.92 (6.23–8.16) |
8.07 ± 2.63 (5.31–10.83) |
| Cardiac arterial events (infarction) | 6.05 ± 0.57 (5.45–6.65) |
6.74 ± 0.41 (6.31–7.17) |
2.79 ± 0.35 (2.41–3.16) |
5.81 ± 1.89 (3.82–7.80) |
6.64 ± 0.63 (5.98–7.30) |
7.83 ± 0.47 (7.33–8.32) |
2.30 ± 0.29 (1.99–2.61) |
4.23 ± 1.38 (2.78–5.67) |
| Cerebral arterial events | 8.05 ± 0.76 (7.24–8.85) |
8.91 ± 0.54 (8.34–9.48) |
3.26 ± 0.42 (2.83–3.70) |
6.03 ± 1.96 (3.96–8.09) |
21.07 ± 2.00 (18.97–23.17) |
20.68 ± 1.26 (19.36–22.0) |
2.46 ± 0.31 (2.13–2.79) |
4.89 ± 1.59 (3.22–6.56) |
| Other arterial events | 9.79 ± 0.93 (8.82–10.77) |
19.73 ± 1.20 (18.47–20.98) |
5.60 ± 0.71 (4.85–6.34) |
18.66 ± 6.08 (12.28–25.04) |
20.20 ± 1.92 (18.19–22.22) |
34.81 ± 2.12 (32.59–37.03) |
5.10 ± 0.65 (4.41–5.78) |
21.34 ± 6.95 (14.05–28.64) |
| Cardiac arterial events (infarction) | 6.05 ± 0.57 (5.45–6.65) |
6.74 ± 0.41 (6.31–7.17) |
2.79 ± 0.35 (2.41–3.16) |
5.81 ± 1.89 (3.82–7.80) |
6.55 ± 0.62 (5.89–7.20) |
7.83 ± 0.47 (7.33–8.32) |
2.30 ± 0.29 (2.00–2.61) |
4.23 ± 1.38 (2.78–5.67) |
| Cardiac arrhythmias | 2.99 ± 0.28 (2.70–3.29) |
0.82 ± 0.05 (0.77–0.87) |
2.14 ± 0.27 (1.85–2.42) |
2.17 ± 0.71 (1.43–2.91) |
3.79 ± 0.36 (3.41–4.17) |
3.37 ± 0.20 (3.16–3.59) |
1.46 ± 0.19 (1.26–1.65) |
2.26 ± 0.74 (1.49–3.04) |
| Cardiac inflammations | 1.25 ± 0.12 (1.12–1.37) |
0.80 ± 0.05 (0.75–0.84) |
1.32 ± 0.17 (1.15–1.50) |
0.97 ± 0.32 (0.64–1.31) |
3.37 ± 0.32 (3.03–3.70) |
N.A.a | 1.22 ± 0.16 (1.05–1.38) |
N.A.a |
| Stroke | 8.11 ± 0.75 (7.32–8.90) |
8.99 ± 0.67 (8.29–9.70) |
3.29 ± 0.44 (2.83–3.75) |
6.06 ± 1.92 (4.04–8.08) |
21.23 ± 1.97 (19.17–23.30) |
20.86 ± 1.54 (19.24–22.48) |
2.48 ± 0.33 (2.13–2.83) |
4.92 ± 1.56 (3.28–6.56) |
| Venous stroke | 24.83 ± 2.36 (22.35–27.31) |
20.21 ± 1.23 (18.92–21.50) |
7.59 ± 0.97 (6.57–8.60) |
10.36 ± 3.38 (6.82–13.90) |
58.66 ± 5.58 (52.80–64.51) |
30.23 ± 1.84 (28.30–32.15) |
13.90 ± 1.77 (12.05–15.76) |
15.37 ± 5.01 (10.11–20.62) |
| Nervous system hemorrhage | 11.42 ± 1.09 (10.28–12.56) |
7.98 ± 0.48 (7.47–8.49) |
2.63 ± 0.34 (2.28–2.98) |
4.49 ± 1.46 (2.95–6.02) |
20.62 ± 1.96 (18.56–22.67) |
11.41 ± 0.69 (10.68–12.14) |
1.84 ± 0.23 (1.60–2.09) |
2.22 ± 0.72 (1.46–2.98) |
| Cranial nerves | 2.26 ± 0.22 (2.03–2.48) |
0.76 ± 0.05 (0.71–0.80) |
2.11 ± 0.27 (1.83–2.39) |
1.55 ± 0.51 (1.02–2.08) |
N.A.b | N.A.c | N.A.c | N.A.c |
a
No death events reported for AD26 vaccine.
b
No death events reported for BNT vaccine.
c
No death events reported for both vaccines.