Table 1.
g) Adapted from Hausmann et al. Comparison of SARS-CoV-2 S Antibody response rate and median antibody titre after vaccination between hemodialysis patients and healthy controls/medical personnel using the median and the interquartile range.
| dialysis patients | p-value | medical personnel (healthy controls) | kidney transplant recipients | p-value | test method | cut-off / unit (upper limit of test) | |
|---|---|---|---|---|---|---|---|
| Danthu et al., CJASN 2021 | RR 81% (N=78) Ab titre 278 (83-526) | < 0.001 | RR 100% (N= 7) Ab titre 1082 (735-1662) | LIAISON SARS-CoV-2 TrimericS IgG (DiaSorin) | > 13 AU/ml | ||
| Espi et al., Kidney Int 2021 | RR 82% (N=106) Ab titre 176 | < 0.001 | RR 100% (N=30) Significant higher titre, but no median reported | Maglumi® SARS-CoV-2 S-RBD IgG test(Snibe Diagnostic) | > 1 AU/ml | ||
| Grupper et al., CJASN 2021 | RR 96% (N=56) Ab titre 2900 (1128-5651) | < 0.001 | RR 100% (N=95) Ab titre 7401 (3687-15471) | SARS-CoV-2 IgG II (Abbott) | > 50 AU/ml | ||
| Jahn et al., vaccines 2021 | RR 93% (N=72) Ab titer titre.5 (89.6-606) | < 0.001 | 100% (N=16) Ab titre 800 (520-800) | LIAISON® SARS-CoV-2 TrimericS IgG (Diasorin) | AU/ml | ||
| Simon et al., NDT 2021 | RR 91% (N=81) Ab titre 171 | < 0.001 | RR 100% (N=80) Ab titre 2500 | Elecsys Anti-SARS-CoV-2 S (Roche) | > 0,4 U/ml | ||
| Paal et al., CKJ 2021 | RR 96.6% (N=179) Ab titre 253.5 (64.2 - 679) | < 0.001 | RR 97.1%(N=70) ##Ab titre 1756 (971.5- 2436.5 | Elecsys Anti-SARS-CoV-2 S (Roche) | > 0,8 U/ml | ||
| Yanay et al., Kidney Int 2021 | RR 90% (N=160) Ab titre 116.5 (66-160) | < 0.001 | RR 100% (N=132) Ab titre 176.5 (142-235) | LIAISON SARS-CoV-2 TrimericS IgG (DiaSorin) | AU/ml | ||
| Stumpf et al., Lancet Regional Health 2021 | |||||||
| IgG S1 SARS-CoV-2-Ab | RR 94.5 % (N = 1074 of 1136) Ab titre 384 (384 - 384) | < 0.001 | RR 98.5 % (N = 132 of 134) Ab titre 384 (384 - 384) | RR 33.6 % (N = 112 of 333) Ab titre 8.0 (3.2 - 127.1) | < 0.001 | SARS-CoV-2-QuantiVac (Euroimmun) | ≥ 35.2 BAU/ml(> 384 BAU/ml) |
Figure 1g) shows a table, adapted from Hasmann et al. For further comparison, SARS-CoV-2 S1 antibody response rate and median antibody titres after vaccination in transplant recipients are also included. Within these groups comparison of all vaccination related study participants (not just the positive responding as shown above in figures 1a-d) are being considered. * response rate (RR), defined as antibody titre above the cut-off of the assay antibody (Ab). # p-value comparing the median Ab titre, if reported ## cohort of non dialysis patients.
Data analysis and graphics were performed using the statistical software R[13] and the ggplot2 package[14]. The following tests were used: Kruskal–Wallis test for comparisons among groups; Wilcoxon test for paired groups. For significance levels in the figures 1a-f, p<0.05 = *, p<0.01 = **, p<0.001 = *** and p<0.0001 = ****.