Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of the genome architecture of the three coronaviruses
SARS-CoV, MERS-CoV, and SARS-CoV-2 have a single-stranded RNA genome, which comprises ~22 kb of two large genes, ORF1a and ORF1b, and 5–7 kb of structural genes encoding structural proteins, spike (S), envelope (E), membrane (M), nucleocapsid (N), and accessory proteins. Different coronaviruses contain unique characteristics in terms of the number, genomic organization, and sequence of accessory genes.
