Table 1. Comparison of reports which studied microglial process motility in the healthy retina and brain. Notes: Measured velocities are mean ± standard deviation, except for Nimmerjahn et al. 2005, which reported standard error of mean. ‘Inst.’ is instantaneous.
| Study | Species | Organ | Technique | Conclusion about process motility | Measured velocities (µm/min) | Inst. velocity range (µm/min) | λ (nm) | Power levels (µW) | Sample size |
|---|---|---|---|---|---|---|---|---|---|
| Current Study | Mouse | Retina (in vivo) | AOSLO | Motile | 0.6 ± 0.4 | 0 - 7.6 | 488 | 53 | 7 mice, 26 cells, 129 processes |
| 796 | 212 | ||||||||
| Nimmerjahn et al. 2005 | Mouse | Brain (in vivo) | Two-photon imaging | Motile | 1.5 ± 0.1 | 0.4 - 3.8 | 840 - 930 | 9000 - 18000 | 8 mice, 14 cells, 242 measures |
| Lee et al. 2008 | Mouse | Retina (ex vivo) | Microscopy retinal explant | Motile | 5.4 ± 2.3 | - | - | - | 3 mice, 37 cells, 367 processes |
| Alt et al. 2010 | Mouse | Retina (in vivo) | AOSLO | Motile | Not quantified | - | 491 | 500 - 1000 | - |
| Alt and Lin 2012 | Mouse | Retina (in vivo) | SLO | Motile | 7.8 ± 2.1 | - | 491 | - | - |
| Wahl et al. 2019 | Mouse | Retina (in vivo) | AOSLO | Motile | 1.3 and 4.8 | - | 488 | 100 - 230 | 1 cell, 2 processes |
| Miller et al. 2019 | Mouse | Retina (in vivo) | SLO | Not motile | Not motile | - | 488 | 100 | - |
| Hammer et al. 2020 | Human | Retina (in vivo) | AO-OCT | Motile | 15.9 ± 2.0 | - | - | - | 6 subjects, 36 cells, 75 processes |