Table 1. Characteristics of patients with breast cancers in the grade 1 and grade 2/3 groups. a .
| characteristics | Training cohort (328) |
Validation cohort (215) |
||||
|---|---|---|---|---|---|---|
| Grade 1 (n=63) | Grade 2/3 (n=265) | P | Grade 1 (n=36) | Grade 2/3 (n=179) | P | |
| Age | 0.593 | 0.785 | ||||
| ≤50 | 35 (55.6%) | 157 (59.2%) | 21 (58.3%) | 100 (55.9%) | ||
| >50 | 28 (44.4%) | 108 (48.8%) | 15 (41.7%) | 79 (44.1%) | ||
| Molecular subtype | 3.28E-04 | 0.020 | ||||
| Luminal A | 26 (41.3%) | 47 (17.7%) | 12 (33.3%) | 23 (12.8%) | ||
| Luminal B | 20 (31.7%) | 113 (42.6%) | 11 (30.6%) | 80 (44.7%) | ||
| HER2-enriched | 13 (20.6%) | 57 (21.5%) | 8 (22.2%) | 39 (21.8%) | ||
| Triple-negative | 4 (6.4%) | 48 (18.2%) | 5 (13.9%) | 37 (20.7%) | ||
| Tumor size | 0.007 | 0.426 | ||||
| ≤2cm | 36 (57.1%) | 95 (35.8%) | 18 (50.0%) | 69 (38.5%) | ||
| 2-5cm | 25 (39.7%) | 149 (56.2%) | 16 (44.4%) | 95 (53.1%) | ||
| >5cm | 2 (3.2%) | 21 (7.9%) | 2 (5.6%) | 15 (8.4%) | ||
| Nodal status | 0.013 | 0.167 | ||||
| 0 | 43 (68.3%) | 128 (48.3%) | 21 (58.3%) | 78 (43.6%) | ||
| 1-3 | 12 (19.0%) | 68 (25.7%) | 8 (22.2%) | 39 (21.8%) | ||
| ≥4 | 8 (12.7%) | 69 (26.0%) | 7 (19.5%) | 62 (34.6%) | ||
| TACS-score median (IQR) | 1.152 (0.732-1.613) | 1.822 (1.253-2.177) | 4.00E-08 | 0.992 (0.678-1.427) | 1.705 (1.206-2.044) | 1.07E-05 |
| TCMF-score median (IQR) | 0.717 (0.032-1.411) | 1.949 (1.391-2.502) | 1.46E-14 | 0.583 (0.024-1.413) | 2.011 (1.264-2.461) | 7.54E-09 |
a
Abbreviations: IQR, interquartile range.