(b) EMT-related genes were significantly downregulated by berberine
| Gene_name | Trans_name | Description | Fold_change | p_value |
|---|---|---|---|---|
| 12 h/0 h | ||||
| MMP28 | MMP28-201 | Matrix metallopeptidase 28 | 0.5887 | 0.0398 |
| VIM | VIM-204 | Vimentin | 0.6486 | 0.0102 |
| TMEM42 | TMEM42-201 | Transmembrane protein 42 | 0.6486 | 0.0103 |
| 24 h/0 h | ||||
| SMAD3 | SMAD3-203 | SMAD family member 3 | 0.3696 | 0.0338 |
| VIM | VIM-204 | Vimentin | 0.3877 | 0.0003 |
| EMP3 | EMP3-202 | Epithelial membrane protein 3 | 0.4737 | 0.0120 |
| VIM | VIM-209 | Vimentin | 0.5447 | 0.0011 |
| MMP28 | MMP28-201 | Matrix metallopeptidase 28 | 0.5590 | 0.0101 |
| 24 h/12 h | ||||
| VIM | VIM-204 | Vimentin | 0.5979 | 0.0115 |
| VIM | VIM-209 | Vimentin | 0.6398 | 0.0036 |
(a) and (b) The level of transcriptional was significantly upregulated and downregulated BBR treatment related to EMT genes (difference from large to small).