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. 2021 Oct 19;2021:2999296. doi: 10.1155/2021/2999296

Figure 4.

Figure 4

Activation of SIRT1 alleviates CIN. CIN was induced by the intravenous injection of the CM iopromide (1.8 g/kg). The SIRT1 inhibitor EX527 (500 mg/kg) or/and SIRT1-specific activator SRT1720 (500 mg/kg) were injected intravenously before establishment of CIN. The kidney samples were collected 24 h after CM injection. (a1) Representative HE staining of kidney sections and (a2) pathological scores. Serum Cr (b) and BUN (c) levels of rats were measured 24 h after CM injection. (d) CCr was measured 24 h after CM injection. The values are presented as mean ± standard deviation (n = 7, ∗P < 0.05 vs. control, #P < 0.05 vs. CM alone, and &P < 0.05 vs. CM+SRT1720).