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. 2021 Oct 19;2021:2999296. doi: 10.1155/2021/2999296

Figure 6.

Figure 6

Fer-1 prevented renal injury in CIN. SD rats were pretreated with Fer-1 for 30 min, followed by injection of CM and euthanasia at 24 h. (a1) Fer-1 decreased histologic injury in kidneys from rats exposed to CM (scale bar = 100 μm). (a2) Pathological scores were calculated. Serum Cr (b) and BUN (c) levels were measured 24 h after CM injection. (d1) Tissue oxidative stress level in the renal outer medulla, measured using DHE (scale bar = 50 μm). (d2) The quantitative mean fluorescence intensity in each treatment group is shown. The renal levels of MDA (e) and GSH/GSSG ratio (f) were measured to determine the oxidative stress. The values are presented as mean ± standard deviation (n = 7, ∗P < 0.05 vs. control, &P < 0.05 vs. CM).