Table 1.

Behavioural testing regimen.

Age (wk)	Procedure	Outcome
14–17	Elevated plus maze test for anxiety-like behaviour	Males—Reduced overall entries
15–18	Locomotor activity and exploration in a 1-h open field test	No differences
	Wire-hang test for grip-strength	No differences
16–19	Accelerating rotarod test	Female—impairments in trials 4 and 5
	Trials 1–3 (first test); trials 4 and 5 (second test, 48 h later)
17–20	Social approach in a three-chamber choice task	No differences
18–21	Marble-bury assay for anxiety and perseverative responses	No differences
	Prepulse inhibition of acoustic startle responses	Males—Reduced startle and PPI
19–24	Buried food test for olfactory ability	No differences
20–25	Morris water maze; visible platform test	Males—Reduced swim speed
21–27	Morris water maze; acquisition of spatial learning	Females—improved probe trial
23–28	Second acoustic startle test	No differences
	Hot plate test for thermal sensitivity	No differences
26–31	Conditioned fear test for contextual and cue learning	No differences
28–33	Second fear test for memory retention	No differences
31–36	Accelerating rotarod, trials 6 and 7	No differences
32–37	Accelerating and fixed speed rotarod (1 min trials)	No differences
50–61	Accelerating rotarod, trials 8 and 9	No differences
56–66	Rapid-reversal rotarod test (2 trials)	Males and females—impaired
58–67	Fixed speed rotarod (2 min trials)	No differences