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. 2021 Oct 26;11:21049. doi: 10.1038/s41598-021-00485-2

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression profiles of used candidate genes at transcriptomic level after treatment with catechol at 37° C for 8 h. The genes responsible for adhesion, filamentous growth and biofilm formation such as HWP1, RAS1, and ALS3 were significantly downregulated in catechol treated cells. TUP1, a negative transcription regulator of filamentation was upregulated. The relative gene expression was calculated by 2^−ΔΔCT method using C. albicans ITS region as housekeeping internal control gene. Error bars indicates the mean values of three experimental duplicates. The “* “and “**” symbols represents the statistical significance of p < 0.05 and p < 0.01, respectively.