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. 2021 Oct 26;11:21090. doi: 10.1038/s41598-021-00434-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Top panel: Image of the lab-based prototype of the binocular pupillometer. A1 and A2—LED screens 1 and 2, B1 and B2—the reflective mirrors, C—the cold mirrors inclined at an angle of 45 degrees. Middle panel: The zoomed in picture of the cold mirror and headrest. Bottom panel: Healthy subject with the head positioned at the device’s headrest. (B) The Schematic illustration of Haploscope-based pupillometer system that shows the image acquisition module with an infrared-based eye tracker and two Light Emitting Diode display monitors with two identical dichroic/cold mirrors in the optical path.