Table 3.
The univariable and multivariable Cox proportional hazards models for risk factors of ATE.
| Variable | HR per | Univariable | Multivariable | ||
|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||
| Age | 1 year | 1.05 (1.01–1.1) | 0.02 | 1.05 (1.005–1.1) | 0.03 |
| Male sex | No/Yes | 0.81 (0.34–1.91) | 0.62 | 0.68 (0.28–1.65) | 0.4 |
| Duration of anticoagulation | 1 month | 1.07 (0.96–1.19) | 0.23 | ||
| Unprovoked VTE | No/Yes | 1.09 (0.46–2.56) | 0.85 | ||
| Smoking | No/Yes | 1.15 (0.47–2.76) | 0.76 | ||
| Diabetes | No/Yes | 3.96 (1.17–13.45) | 0.03 | 3.75 (1.08–12.98) | 0.04 |
| Hypercholesterolemia | No/Yes | 1.06 (0.36–3.15) | 0.92 | ||
| CRP | 1 mg/L | 0.86 (0.58–1.27) | 0.45 | ||
| Fibrinogen | 1 g/L | 1.3 (0.84–2.03) | 0.24 | 1.46 (0.92–2.3) | 0.1 |
| D-dimer | 100 mg/dL | 0.99 (0.64–1.54) | 0.98 | ||
| ETP | 0.001 nM x min | 0.58 (0.1–3.21) | 0.53 | ||
| Ks | 1 × 10–9 cm2 | 0.69 (0.45–1.04) | 0.08 | ||
| Lag phase | 1 s | 0.98 (0.9–1.07) | 0.65 | ||
| ΔAbs | 0.01 | 1.06 (0.99–1.13) | 0.11 | ||
| D-Dmax | 1 mg/L | 1.45 (0.66–3.17) | 0.35 | ||
| D-Drate | 0.001 mg/L/min | 1.07 (1.01–1.13) | 0.01 | 1.08 (1.02–1.14) | 0.01 |
| CLT | 1 min | 0.99 (0.97–1.02) | 0.63 | ||
| Recurrent VTE | No/Yes | 0.81 (0.3–2.2) | 0.68 | 0.04 (0.35–3.09) | 0.94 |
HR hazard ratio, CI confidence interval, CRP C-reactive protein, ETP endogenous thrombin potential, for other abbreviations see Tables 1 and Table 2.
In terms of ATE two patients excluded from the previous analysis were included in the current follow-up study.
Twenty-one patients with ATE and 289 patients without ATE were included in the Cox proportional hazards models.
Age, gender, diabetes, fibrinogen, D-D rate and recurrent VTE were included in the multivariable model.
C-statistic = 0.73.