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. 2021 Oct 26;4:1227. doi: 10.1038/s42003-021-02715-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Daily alcohol intake (left) and average alcohol intake (right) of control and Bmal1 heterozygote male mice. Two-way repeated measure ANOVA (RM-ANOVA), no significant effect, F (1, 26) = 2.793, p = 0.1067, Unpaired two-tailed t-test, NS. b Daily alcohol intake (left) and average alcohol intake (right) of control and Bmal1 heterozygote female mice. RM-ANOVA, no significant effect, F (1, 25) = 2.507, p = 0.1259, Unpaired two-tailed t-test, NS. c Daily alcohol preference (left) and average alcohol preference (right) of control and Bmal1 heterozygote male mice. RM-ANOVA, no significant effect, F (1, 26) = 1.326, p = 0.26, Unpaired two-tailed t-test, NS. d Daily alcohol preference (left) and average alcohol preference (right) of control and Bmal1 heterozygote female mice. RM-ANOVA, no significant effect, F (1, 25) = 3.506, p = 0.0729, Unpaired two tailed t-test, NS. e Total fluid intake (left) and average fluid intake (right) of control and Bmal1 heterozygote male mice. RM-ANOVA, no significant effect, F (91, 26) = 1.498, p = 0.2320, Unpaired two-tailed t-test, NS. f Total fluid intake (left) and average fluid intake (right) of control and Bmal1 heterozygote female mice. RM-ANOVA, no significant effect, F (1, 25) = 0.5874, p = 0.4506, Unpaired two-tailed t-test, NS. g Daily alcohol intake (left) and average alcohol intake (right) of control and Per2 heterozygote male mice. RM-ANOVA, no significant effect, F (1, 13) = 0.09317, p = 0.7650. Unpaired two-tailed t-test, NS. h Daily alcohol intake (left) and average alcohol intake (right) of control and Per2 heterozygote female mice. RM-ANOVA, no significant effect, F (1, 13) = 0.08137. p = 0.7799. Unpaired two-tailed t-test, NS. i Daily alcohol preference (left) and average alcohol preference (right) of control and Per2 heterozygote male mice. RM-ANOVA, no significant effect, F (1, 13) = 0.01314, p = 0.9105. Unpaired two-tailed t-test, NS. j Daily alcohol preference (left) and average alcohol preference (right) of control and Pe2 heterozygote female mice. RM-ANOVA, no significant effect, F (1, 13) = 0.04381, p = 0.8375. Unpaired two-tailed t-test, NS. k Total fluid intake (left) and average fluid intake (right) of control and Per2 heterozygote male mice. RM-ANOVA, no significant effect, F (1, 13) = 0.02780, p = 0.8702. Unpaired two-tailed t-test, NS. l Total fluid intake (left) and average fluid intake (right) of control and Per2 heterozygote female mice. RM-ANOVA, no significant effect, F (1, 13) = 1.833, p = 0.1988. Unpaired two tailed t-test, NS. NS = no significant differences. The values express mean ± S.E.M. a–f, CTR: control, HET: Bmal1 heterozygote. a, c, e CTR n = 12, HET n = 16. b, d, f CTR n = 17, HET n = 10. g–l CTR: control, HET: Per2 heterozygote. g, i, k CTR n = 8, HET n = 7. h, j, l CTR n = 9, HET n = 6.