TABLE 1.
Clinical characteristics of patients, stratified by the presence of troponin dynamic changes.
|
Troponin dynamic changes
|
P | ||
| Yes (n = 66) | No (n = 226) | ||
| Age, years (IQR) | 81 (69–83) | 69 (61–79) | < 0.001 |
| Male, n (%) | 34 (51.5%) | 158 (69.9%) | 0.006 |
| Vascular risk factors | |||
| Hypertension, n (%) | 52 (78.8%) | 173 (76.5%) | 0.70 |
| Diabetes mellitus, n (%) | 15 (22.7%) | 78 (34.5%) | 0.071 |
| Hyperlipidemia, n (%) | 24 (36.4%) | 85 (37.6%) | 0.85 |
| Current Smoking, n (%) | 15 (22.7%) | 53 (23.5%) | 0.90 |
| Comorbidities | |||
| Atrial fibrillation, n (%) | 36 (54.5%) | 67 (29.6%) | < 0.001 |
| Coronary artery disease, n (%) | 12 (18.2%) | 17 (7.5%) | 0.011 |
| Previous stroke, n (%) | 12 (18.2%) | 24 (10.6%) | 0.10 |
| Treatment status | |||
| OTT, min (mean ± SD) | 157.8 ± 54.4 | 167.4 ± 56.7 | 0.24 |
| Ongoing antithrombotic therapy, n (%) | 12 (18.2%) | 32 (14.2%) | 0.42 |
| Bridge therapy, n (%) | 12 (18.2%) | 30 (13.3%) | 0.32 |
| NIHSS score (IQR) | 14 (9–18) | 6 (4–12) | < 0.001 |
| Baseline SBP, mmHg (mean ± SD) | 161.8 ± 25.3 | 159.4 ± 22.5 | 0.45 |
| Baseline DBP, mmHg (mean ± SD) | 88.3 ± 18.9 | 88.9 ± 15.8 | 0.79 |
| Ejection fraction,% (IQR) | 62 (58–67) | 65 (61–68) | 0.001 |
| HT, n (%) | 21 (31.8%) | 30 (13.3%) | < 0.001 |
| Laboratory test | |||
| Troponin elevation on admission, n (%) | 26 (39.4%) | 7 (3.1%) | < 0.001 |
| Baseline blood glucose, mmol/L (IQR) | 6.88 (5.88–9.16) | 7.19 (6.09–9.35) | 0.35 |
| Platelet, 109/L (IQR) | 191 (158–226) | 189 (165–227) | 1.00 |
| INR (IQR) | 1.06 (1.00–1.12) | 1.03 (0.98–1.09) | 0.011 |
| Creatinine, umol/L (IQR) | 84 (65–105) | 69 (59–83) | < 0.001 |
| HbA1c,% (IQR) | 5.70 (5.45–6.10) | 5.91 (5.50–6.68) | 0.065 |
| TC, mmol/L (IQR) | 4.11 (3.61–4.96) | 4.22 (3.69–5.12) | 0.43 |
| LDL_C, mmol/L (IQR) | 2.33 (1.87–3.17) | 2.58 (2.11–3.34) | 0.11 |
| Stroke etiology | 0.002 | ||
| Large artery atherosclerosis | 18 (27.3) | 69 (30.5) | |
| Cardioembolism | 36 (54.5) | 67 (29.6) | |
| Small vessel occlusion | 5 (7.6) | 54 (23.9) | |
| Other determined | 1 (1.5) | 8 (3.5) | |
| Undetermined | 6 (9.1) | 28 (12.4) | |
DBP, diastolic blood pressure; HT, hemorrhagic transformation; INR, international normalized ratio; IQR, interquartile range; LDL-C, low-density lipoprotein cholesterol; NIHSS, National Institutes of Health Stroke Scale; OTT, onset-to-treatment time; SBP, systolic blood pressure; SD, standard deviation; TC, total cholesterol. The bold values represent significant results in univariate analysis (P < 0.05).