Table 3.
Pathogens and ATG machinery targets in infectious diseases
| Infectious diseases | Target | Models | Ref |
|---|---|---|---|
| Bacterial infection | |||
| Gastroenteritis (Salmonella enterica serovar Typhimurium infection) | ULK1, ATG16L1 | Mouse model and cell culture | (Liu et al., 2019; Tan et al., 2018; Xu et al., 2019) |
| Tuberculosis (Mycobacterium tuberculosis infection) | ATG5, SQSTM1, CALCOCO2 | Mouse model and cell culture | (Castillo et al., 2012) |
| Group A Streptococcus | ATG5 | Cell culture | (Nakagawa et al., 2004) |
| Legionella pneumophila | LC3 | Cell culture | (Choy et al., 2012) |
| Listeria monocytogenes | SQSTM1, LC3 | Mouse model and cell culture | (Yoshikawa et al., 2009) |
| Shigella flexneri | ATG5 | Mouse model and cell culture | (Ogawa et al., 2005) |
| Fungal infection | |||
| Cryptococcus neoformans and Candida albicans | ATG5 | Mouse model | (Nicola et al., 2012) |
| Viral infection | |||
| Coxsackievirus B3 | ATG5, SQSTM1 | Mouse model and cell culture | (Alirezaei et al., 2012) (Shi et al., 2013) |
| Hepatitis C virus (HCV) | BECN1, ATG7 | Cell culture | (Shrivastava et al., 2011) |
| Herpes simplex virus type 1 (HSV-1) | BECN1 | Mouse model and cell culture | (Leib et al., 2009) |
| Human immunodeficiency virus (HIV) | BECN1 | Cell culture | (Kyei et al., 2009) |
| Influenza | ATG5 | Mouse model and cell culture | (Schlie et al., 2015) |
| Murine γ-herpesvirus 68 (MHV-68) | BECN1 | Mouse model and cell culture | (Xiaofei et al., 2009) |
| Poliovirus | LC3 | Cell culture | (Taylor and Kirkegaard, 2007) |