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. 2021 Oct 13;12:773918. doi: 10.3389/fphar.2021.773918

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Copyright © 2021 Zhang, Liu, Tang, Shao, Hua, Liu, Yang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of NONHSAT114552 affected chordoma cells (U-CH1 and U-CH2) proliferation, invasion and migration (A). Left, NONHSAT114552 relative expression was assessed after U-CH1 or U-CH2 cells were transfected with sh-NONHSAT114552. Right, knockdown of NONHSAT114552 significantly inhibited U-CH1 or U-CH2 cell viability (B). Colony formation assays showed that knockdown of NONHSAT114552 significantly restrained the proliferation of U-CH1 or U-CH2 cells (C). Wound healing assays demonstrated that deletion of NONHSAT114552 refrained migration of chordoma cells (D). Transwell assays were conducted for assessing U-CH1 or U-CH2 cell invasion with NONHSAT114552 knockdown.