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. 2021 Oct 13;12:773918. doi: 10.3389/fphar.2021.773918

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Copyright © 2021 Zhang, Liu, Tang, Shao, Hua, Liu, Yang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NONHSAT114552 directly targets miR-320d in chordoma (A, B). Bioinformatic analysis identified miR-320d binding sites in the 3′UTR of NONHSAT114552 and luciferase reporter plasmid including NONHSAT114552-WT or NONHSAT114552-Mut was subsequently shown (C). On the basis of luciferase reporter assay, miR-320d significantly decreased luciferase signals of NONHSAT114552-WT reporters, but did not affect NONHSAT114552-Mut reporters (D). FISH assay showed location of NONHSAT114552 in U-CH1 cells (E). miR-320d relative expression level was significantly up-regulated after knockdown of NONHSAT114552.