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. 2021 Oct 26;11:21125. doi: 10.1038/s41598-021-00576-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the per-individual number of derived alleles (N_alleles) and homozygous derived genotypes (N_hom) across populations for variants in different GERP RS score categories. Pairwise population ratios of the mean per-individual number of derived alleles and homozygous derived genotypes. Plot title indicates the range of GERP RS scores of the variants included. Error bars represent the 0.025 and 0.975 quantiles obtained by bootstrapping by site 1000 times, dividing the exome data into 1000 blocks and performing bootstrap resampling of blocks 1000 times. Statistical significance is shown in the following way: *p < 0.05, **p < 0.01, ***p < 0.001. To account for multiple testing errors, significance threshold was set to p < 0.001. Population names abbreviated as in Fig. 1.