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. 2021 Oct 26;12(11):1003. doi: 10.1038/s41419-021-04282-7

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© The Author(s) 2021, corrected publication 2025

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Fig. 1 — CGI-58^fl/fl and CGI-58^cko mice were fed with ND or HFD for 3 months. A, B The survival rate and body weight of CGI-58^fl/fl and CGI-58^cko mice (n = 10). C M-model echocardiography of the left ventricle (upper). Measurement of ejection fraction (EF%) and fractional shortening (FS%) (lower, n = 8). D Heart size (upper), heart weight, and heart weight to tibia length (HW/TL) ratio (lower, n = 8). Scale bar 2 mm. E Wheat germ agglutinin (WGA) staining of heart sections (upper) and the quantification of cardiac myocyte size (lower). Scale bar 50 μm (n = 5). F Masson’s Trichrome staining of heart sections (upper) and the quantification of the relative fibrosis area (lower, n = 5). G, H qPCR analyses of ANF, BNP, Myh7, collagen I and collagen III mRNA levels (n = 5). Data are presented as mean ± SEM, and n represents the number of animals per group. *P < 0.05, **P < 0.01, ***P < 0.001.