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. 2021 Oct 26;12(11):1003. doi: 10.1038/s41419-021-04282-7

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© The Author(s) 2021, corrected publication 2025

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A–D GO and KEGG pathway analysis of the biological processes in the hearts from CGI-58^fl/fl and CGI-58^cko mice. The pathways involved in ER stress, phagosome, lysosome, and fatty acid metabolism are significantly enriched in CGI-58^cko hearts. The horizontal axis represents −log10 (Fisher’ exact value); the ordinate represents the GO or KEGG pathway. E The heatmap illustrates the expression level changes of the statistically significant proteins involved in ER stress, phagosome, lysosome, and fatty acid metabolism between the CGI-58^fl/fl and CGI-58^cko mice.