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. 2021 Oct 26;11:21100. doi: 10.1038/s41598-021-00579-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phenotypic analysis of Sec24c^+/c-d intercross progeny at P0. (A) Side views of P0 pups from Sec24c^+/c-d intercross taken shortly after birth. Sec24c^c-d/c-d pups are much paler and smaller than their littermate controls, exhibited little spontaneous movement, and died within minutes of birth. (B) Body weight measurements at P0, 4 weeks, and 6 weeks of age. P0 normalized to average weight of controls (Sec24c^+/+ and Sec24c^+/c-d) within the same litter set at 100%. Four week and 6 week data normalized to the average weight of wild type mice for each sex; data for males and females are pooled; no significant differences in weight were observed between Sec24c^+/+ and Sec24c^+/c-d mice when broken down by sex. (C) Crown to rump length measurements at P0, normalized to average length of controls (Sec24c^+/+ and Sec24c^+/c-d) within the same litter. ** indicates p < 0.0001; all other comparisons not significant, with p > 0.05. Error bars represent the standard deviation.