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. 2021 Oct 26;11:21079. doi: 10.1038/s41598-021-00649-0

Table 3.

Variation of different progression parameters between measurements (12 ± 3 months apart) in groups with or without KCE progression.

No progression in KCE (n = 50) Progression in KCE (n = 63) P value
ΔKmax (mean, SD) − 0.02 1.019 0.78 1.467 0.001
ΔKm (median/IQR) − 0.10 0.30 0.50 0.70  < 0.001
ΔK1 (mean, SD) − 0.05 0.251 0.59 0.593  < 0.001
ΔK2 (mean, SD) − 0.07 0.503 0.76 0.803  < 0.001
ΔISV (mean, SD) 0.64 3.439 3.14 9.411 0.054
ΔARTmax (median/IQR) − 4.00 35.00 − 3.00 27.00 0.178
ΔPakmin (mean, SD) 1.61 9.855 − 2.02 11.205 0.073
Δ D-Index (mean, SD) 0.19 0.473 0.56 0.867 0.005
ΔELEBmax (mean, SD) 1.54 3.233 4.06 6.217 0.008
ΔPCR (mean, SD) − 0.05 0.066 − 0.08 0.126 0.152
ΔAstg (mean, SD) − 0.02 0.431 0.17 0.813 0.121

KCE keratoconus enlargement, Kmax maximum keratometry, Km mean keratometry, K1 keratometry of flat meridian, K2 keratometry of steepest meridian, ISV index of surface variance, ARTmax Ambrósio relational thickness maximum, PachyMin minimum pachymetry, D-Index Belin/Ambrósio D-Index, ELEBmax maximum elevation of corneal back surface, PCR posterior radius of curvature from the 3.0 mm centered on the thinnest point, Astig corneal astigmatism, Δ represents the variations of parameter readings between the first and the second measurement after 12 ± 3 months.