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. 2021 Oct 13;11:707618. doi: 10.3389/fonc.2021.707618

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Copyright © 2021 Liu and Rong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Manganese (Mn)-based hybrid nanomaterials as imaging agents and their application in tumor. (A) Diagram of the enhanced MRI of DNA-Mn-based nanoflower (DMNF)-treated tumor-bearing mice (27). (B) Preparation and characterization of DMNF imaging agents (27). (C) Representative T1- and T2-weighted images of mouse brain at pre- and post-contrast points. T1-T2 dual-modal MRI in brain tumor model through the synthesized MRI contrast agents, NOTA conjugated NEB chelating with Mn²⁺ (Mn-NEB) and BSA (Mn-NEB+BSA) (28). DMNF, DNA-Mn-based nanoflower; NOTA, N, N’, N’’-triacetic acid.