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. 2021 Oct 13;11:707618. doi: 10.3389/fonc.2021.707618

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Copyright © 2021 Liu and Rong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mn-based hybrid nanomaterials as carriers for drug delivery and their application in tumor. (A) Schematic illustration of PEG-MnO₂-OPN siRNA (20). (B) Preparation and characterization of GOx-MnCaP-DOX, glucose oxidase (GOx) with manganese-doped calcium phosphate (MnCaP), and doxorubicin (DOX) (39). (C) Tumor cell-selective uptake analysis by confocal laser scanning microscope and in vivo tumor homing behavior evaluation by T1-weighted MRI of arginine-rich manganese silicate nanobubbles loading DOX (AMSNs/DOX) (49). (D) The in vivo antitumor efficacy of GOx-MnCaP-DOX on the 4T1 tumor-bearing mouse model (39). OPN, Osteopontin; GOx, Glucose; MnCaP, manganese-doped calcium phosphate; DOX, doxorubicin; AMSNs, Arginine-rich manganese silicate nanobullles.