Table 2.
Manganese-based hybrid nanomaterials as carriers for drug delivery.
| Delivered molecules | Agent name | Description | Tumor model | Research group and reference |
|---|---|---|---|---|
| DOX | HMnO2 nanoshells | Hollow mesoporous MnO2 (HMnO2) nanoshells with DOX loaded could be used for tumor-specific therapy in pH-responsive MRI. | 4T1 tumor-bearing Balb/c mice | Zhuang Liu’s group (24) |
| DOX | Mn-SS/DOX@PDA-PEG NCPs | Redox-sensitive Mn-SS (disulfide)/DOX@PDA (polydopamine)-PEG polymers (NCPs) for T1-contrast MRI and glutathione (GSH)-responsive release of DOX | 4T1 tumor-bearing mice | Zili Ge and Zhuang Liu’s group (30) |
| DOX | MnO2-PEG-FA/DOX nanosheets | A redox/pH dual responsive nanotheranostic platform, MnO2-PEG-FA/DOX nanosheets through MnO2 nanosheets combined with FA and DOX for MRI and chemotherapy | S180 tumor-nearing mice | Zhenzhong Zhang and Yun Zhang’s group (35) |
| DOX | DOX-GOx-MnCaP NPs | A pH-responsive DOX-loaded glucose oxidase (GOx) with MnCaP spherical nanoparticles for MRI and cascade reaction-enhanced cooperative cancer treatment | 4T1 tumor-bearing mice | Peng Huang’s group (39) |
| DOX | BMDN | MnO2/DOX-loaded albumin nanoparticles (BMDN) for MRI and simultaneous chemotherapy | MCF-7/ADR tumor-bearing mice | Huabing Chen and Hu-Lin Jiang’s group (31) |
| DOX | USMO@MSNs | USMO@MSNs loading DOX for pH-switching MRI and chemotherapy | HSC3 tumor-bearing nude mice | Renfei Wang and Duohong Zou (34) |
| DOX | Hollow MCO NPs | Hollow manganese/cobalt oxide nanoparticles (MCO-70 NPs) with a tunable size for GSH-responsive dual T1/T2-weighted MRI reporting drug release of DOX | U87MG tumor-bearing nude mice | Zhiping Wan, Junqing Hu, and Yijing Liu’s groups (22) |
| PTX | W-PTX-MNPs-PPR | Three shaped Mn-Zn ferrite (Mn0.63Zn0.37Fe2O4) MNPs for more efficient dual-mode MRI/fluorescence imaging-guided drug delivery | 4T1 tumor-bearing mice | Ning Gu and Fei Xiong’s group (41) |
| MTX | MTX-Mn@PEG NCPs |
A chelating agent free, stoichiometry, and pH-responsive NCPs for MRI-guided MTX delivery | HeLa tumor-nearing BALB/c nude mice | Youfu Wang, Dawei Li and Xinyuan Zhu’s group (38) |
| ATO | [Mn(HAsO3)]n@SiO2 | A pH-sensitive multifunctional trioxide (ATO) drug delivery system (MDDS) through hollow silica nanoparticles loading water-insoluble manganese-arsenite complexes (MnAsOx@SiO2) and ATO for real-time monitoring of ATO release by activatable MRI | H22 tumor-nearing BALB/c mice | Jinhao Gao’s group (36) |
| CDDP | MnO2/HA/CDDP nanosheets | MnO2/HA/CDDP nanosheets (MnO2 nanosheets functionalized by HA, with CDDP absorbed) for pH-responsive MRI and delivering CDDP | A549 tumor-bearing mice | Zhenzhong Zhang and Yun Zhang’s group (37) |
| HCQ | HA-Mn2O3/HCQ | TME-responsive drug release and tumor targeting drug carriers-Hollow mesoporous Mn2O3 NPs conjugated with hyaluronic acid (HA) loading hydroxychloroquine (HCQ, traditional autophagy inhibitor) into the hollow core, for MRI-guided in situ autophagy inhibition | 4T1 tumor-bearing BALB/c mice | Lin Hou and Zhenzhong Zhang’s group (21) |
| BPD | MnO2/BPD NPs | MnO2/BPD nanocomposites for vessel embolization therapy with MR, PA, and FL multimodal imaging as a predictor | Hep-G2 tumor-bearing BALB/c mice | Meng Niu, Ke Xu and Jie Tian’s group (19) |
| OPN siRNA | PEG-MnO2-OPN siRNA | PEG-modified MnO2 nanosheets carrying osteopontin (OPN) siRNA for GSH-responsive MRI-guided gene delivery | 786-O tumor-bearing mice | Kai Xua and Jingjing Li’s group (20) |
| 5-Fu | Mn-ZIF-8/5-Fu NPs | A pH-responsive bimetallic zeolitic imidazolate framework (Mn-ZIF-8) loading 5-fluorouracil showing diagnostic (MRI) and improved therapeutic applications in U87-MG tumor-bearing mice | U87-MG tumor-bearing Balb/c nude mice | Jianhua Wang, Anwen Shao, and Jianmin Zhang’s group (40) |
HMnO2, hollow mesoporous MnO2; DOX, doxorubicin; MRI, magnetic resonance imaging; PDA, polydopamine; SS, disulfide; GSH, glutathione; GOx, glucose oxidase; MnCaP, manganese-doped calcium phosphate; BMDN, BSA-MnO2-DOX nanoparticles; USMO@MSNs, Ultrasmall manganese oxide-capped mesoporous silica nanoparticles; MCO-70 NPs, Hollow manganese/cobalt oxide nanoparticles with an average size of 70 nm; MTX, methotrexate; MDDS, multifunctional drug delivery system; MnAsOx@SiO2, hollow silica nanoparticles loading water-insoluble manganese-arsenite complexes; HA, hyaluronic acid; CDDP, cis diamminedichloroplatinum; TME, tumor microenvironment; HA, hyaluronic acid; HCQ, hydroxychloroquine; BPD, benzoporphyrin derivative; Mn2O3, manganese trioxide; OPN, osteopontin; ZIF, zeolitic imidazolate framework.