FIGURE 1.

Identification of constitutive MAEs in BMMCs. (A) Histogram of VAF in BMMCs estimated by UMI counts. AIM expression and MAE are highlighted. (B) Identification of constitutive MAEs, with blue representing MAEs of reference allele while red representing MAEs of the alternative allele. The percentage of the constitutive MAE is shown on the top left of the plot. (C) tSNE projection of BMMCs (background), colored by expressed allele of MEG8. The size of the highlighted dot is scaled to log₁₀ of UMI count. The pie chart in the bottom right shows the genetic allelic ratio of the two alleles from whole-genome sequencing (WGS) data. (D) tSNE projection of BMMCs, colored by expressed allele of RPS14. (E) tSNE projection of BMMCs, colored by expressed allele of BRD2. (F) GO enrichment analysis of the constitutive MAEs in BMMCs.