Figure 4.

C6 exposure in utero did not lead to an increase in repetitive behaviors. (A) Top, graph shows the total time (mean ± SEM) moving during sessions 1 and 2 (S1 and S2). Bottom, total distance traveled (mean ± SEM) as a measure of locomotor activity in the open-field task. The lines linking each S1 and S2 represent the scores for individual animals. (B) Box-and-whisker plots for cumulative time self-grooming show median and Q1–Q3 quartiles (whiskers are 10–90 range). Dots represent individual animals. C6-exposed mice did not exhibit increased self-grooming compared to B1 control groups, irrespective of genotype. (C) Box-and-whisker plots show the number of marbles buried (more than 50% of the surface area covered by bedding) during the marble-burying task. The number of marbles buried was not significantly different between B1- and C6-exposed mice, irrespective of genotype; 2-way ANOVA with Tukey test was used for statistical comparisons. See Table 1 and Supplementary Table 2 for details of statistical testing; ns = non-significant.