TABLE 3.

Univariate and multivariate Cox regression analysis in TCGA-LGG each cohorts.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	p Value	HR (95% CI)	p Value
Training set (n = 305)
Age (<40/≥40)	3.908 (2.214–6.898)	2.5965E-06	2.750 (1.448–5.222)	0.00198857
Gender (female/male)	1.250 (0.765–2.042)	0.372437476	1.974 (1.160–3.360)	0.01221692
Grade (G2/G3)	3.459 (1.972–6.066)	1.49742E-05	1.774 (0.919–3.422)	0.08750485
Radiotherapy (no/yes)	3.045 (1.583–5.854)	0.000844437	1.507 (0.710–1.131)	0.28553912
IDH status (wild/mutation)	0.143 (0.088–0.234)	9.56649E-15	0.465 (0.191–1.131)	0.09129914
Chemotherapy (no/yes)	1.628 (0.977–2.712)	0.061242815	0.820 (0.470–1.432)	0.4854889
Risk score (low/high)	4.645 (3.353–6.435)	2.59641E-20	2.493 (1.336–4.651)	0.0041002
Validation set (n = 128)
Age (<40/≥40)	3.425 (1.427–8.220)	0.005861356	3.319 (1.097–10.05)	0.03372453
Gender (female/male)	0.794 (0.377–1.673)	0.544405373	1.059 (0.461–2.431)	0.89283856
Grade (G2/G3)	3.572 (1.572–8.117)	0.002367324	2.376 (0.817–6.911)	0.11217943
Radiotherapy (no/yes)	1.775 (0.761–4.140)	0.183865679	1.921 (0.669–5.517)	0.22532202
IDH status (wild/mutation)	0.116 (0.047–0.288)	3.63036E-06	0.776 (0.139–4.338)	0.77242088
Chemotherapy (no/yes)	0.865 (0.421–1.778)	0.693438967	0.218 (0.086–0.553)	0.00131428
Risk score (low/high)	4.334 (2.546–7.381)	6.64509E-08	3.583 (1.151–11.16)	0.02762528
Whole set (n = 433)
Age (<40/≥40)	3.541 (2.243–5.590)	5.70336E-08	2.918 (1.717–4.957)	7.4951E-05
Gender (female/male)	1.060 (0.713–1.576)	0.772843899	1.472 (0.964–2.248)	0.07342518
Grade (G2/G3)	3.307 (2.213–5.151)	1.22602E-07	1.880 (1.115–3.170)	0.01789178
Radiotherapy (no/yes)	2.535 (1.516–4.239)	0.000389848	1.484 (0.818–2.692)	0.19380046
IDH status (wild/mutation)	0.147 (0.098–0.222)	5.54714E-20	0.560 (0.272–1.154)	0.11614564
Chemotherapy (no/yes)	1.333 (0.881–2.016)	0.173180772	0.623 (0.394–0.985)	0.04287472
Risk score (low/high)	4.593 (3.487–6.050)	2.04139E-27	2.714 (1.644–4.482)	9.5588E-05