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. 2021 Oct 13;12:758670. doi: 10.3389/fphar.2021.758670

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Copyright © 2021 Jia, Li, Liu, Si, Jin, Wang, Ma and Chu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in myocardial mitochondrion ultrastructure between the ATO group and HES treatment groups (scale bar = 2.0 μm, magnification: 7000 ×). A to E represent the CONT, ATO, HES_L, HES_H, and HES groups, respectively. TEM images show the ultrastructure changes of myocardial mitochondria: the mitochondria were swollen, and the cristal space was enlarged (arrow 1); the crest became short or dissolved and disappeared (arrow 2); the cristae disappeared, and the mitochondria were vesicular (arrow 3); the space between myofilaments was enlarged (arrow 4); and myofilaments broke, dissolved and disappeared (arrow 5).