TABLE 2.
Correlation analysis between CLDN10 and relate genes and markers of immune cells in TIMER2.0.
| Description | Gene markers | STAD | |||
|---|---|---|---|---|---|
| None | Purity | ||||
| Cor | P | Cor | P | ||
| CD8 + T cell | CD8A | −0.063 | 0.198 | −0.077 | 0.133 |
| CD8B | 0.054 | 0.274 | 0.058 | 0.262 | |
| T cell (general) | CD3D | −0.083 | 0.0899 | −0.116 | 0.0245 |
| CD3E | −0.045 | 0.356 | −0.079 | 0.126 | |
| CD2 | −0.066 | 0.18 | −0.091 | 0.0781 | |
| B cell | CD19 | 0.203 | 3.21E-05 | 0.174 | 6.80E-04 |
| CD79A | 0.153 | 1.76E-03 | 0.127 | 1.34E-02 | |
| Monocyte | CD86 | −0.059 | 2.32E-01 | −0.081 | 0.115 |
| CSF1R | 0.027 | 0.589 | −0.003 | 0.954 | |
| TAM | CCL2 | 0.106 | 0.0305 | 0.098 | 0.0569 |
| CD68 | −0.065 | 0.19 | −0.068 | 0.189 | |
| IL10 | 0.049 | 0.32 | 0.02 | 0.698 | |
| M1 Macrophage | NOS2 | −0.169 | 5.54E-04 | −0.19 | 2.04E-04 |
| IRF5 | 0.083 | 9.18E-02 | 0.072 | 0.162 | |
| PTGS2 | 0.111 | 2.34E-02 | 0.099 | 5.40E-02 | |
| M2 Macrophage | CD163 | −0.032 | 0.519 | −0.047 | 0.362 |
| VSIG4 | −0.01 | 0.843 | −0.015 | 0.768 | |
| MS4A4A | 0.007 | 0.887 | −0.007 | 0.888 | |
| Neutrophils | CEACAM8 | 0.08 | 0.106 | 0.078 | 0.127 |
| ITGAM | 0.019 | 0.695 | 0.001 | 0.214 | |
| CCR7 | 0.146 | 2.93E-03 | 0.12 | 1.97E-02 | |
| Natural killer cell | KIR2DL1 | 0.019 | 0.698 | 0.013 | 0.795 |
| KIR2DL3 | −0.052 | 0.289 | −0.063 | 0.224 | |
| KIR2DL4 | −0.129 | 8.65E-03 | −0.132 | 1.01E-02 | |
| KIR3DL1 | −0.047 | 0.344 | −0.048 | 0.349 | |
| KIR3DL2 | −0.062 | 0.206 | −0.071 | 0.17 | |
| KIR3DL3 | −0.053 | 0.278 | −0.056 | 0.274 | |
| KIR2DS4 | −0.087 | 7.65E-02 | −0.094 | 6.71E-02 | |
| Dendritic cell | HLA-DPB1 | −0.038 | 0.437 | −0.064 | 0.21 |
| HLA-DQB1 | −0.079 | 0.11 | −0.103 | 4.49E-02 | |
| HLA-DRA | −0.08 | 0.104 | −0.105 | 4.05E-02 | |
| HLA-DPA1 | −0.052 | 0.29 | −0.076 | 0.141 | |
| CD1C | 0.238 | 9.35E-07 | 0.219 | 1.65E-05 | |
| Th1 | NRP1 | 0.124 | 1.17E-02 | 0.102 | 4.66E-02 |
| ITGAX | −0.008 | 0.878 | −0.031 | 0.547 | |
| TBX21 | −0.056 | 0.256 | −0.085 | 9.76E-02 | |
| STAT1 | −0.13 | 7.81E-03 | −0.139 | 6.69E-03 | |
| IFNG | −0.229 | 2.47E-06 | −0.243 | 1.64E-06 | |
| TNF | 0.021 | 0.677 | −0.01 | 0.845 | |
| Th2 | GATA3 | 0.047 | 0.34 | 0.032 | 0.528 |
| STAT6 | 0.023 | 0.633 | 0.036 | 0.479 | |
| STAT5A | −0.003 | 0.947 | −0.022 | 0.67 | |
| IL13 | −0.037 | 0.455 | −0.058 | 0.262 | |
| Tfh | BCL6 | 0.299 | 4.83E-10 | 0.297 | 3.49E-09 |
| IL21 | −0.09 | 6.64E-02 | −0.109 | 3.34E-02 | |
| Th17 | STAT3 | 0.138 | 5.01E-03 | 0.131 | 1.05E-02 |
| IL17A | −0.052 | 0.292 | −0.064 | 0.215 | |
| Treg | FOXP3 | −0.11 | 2.51E-02 | −0.132 | 1.03E-02 |
| CCR8 | −0.035 | 0.478 | −0.057 | 0.269 | |
| STAT5B | 0.178 | 2.73E-04 | 0.153 | 2.78E-03 | |
| TGFB1 | 0.104 | 3.33E-02 | 0.08 | 0.121 | |
| T cell exhaustion | PD1(PDCD1) | −0.088 | 7.17E-02 | −0.102 | 4.62E-02 |
| CTLA4 | −0.106 | 3.02E-02 | −0.122 | 1.74E-02 | |
| LAG3 | −0.151 | 2.09E-03 | −0.161 | 1.69E-03 | |
| TIM3(HAVCR2) | −0.093 | 5.84E-02 | −0.109 | 3.37E-02 | |
| GZMB | -−0.228 | 2.57E-06 | −0.244 | 1.57E-06 | |
STAD, Stomach adenocarcinoma; TAM, tumor-associated macrophage; Cor, R value of Spearman’s correlation; Purity, correlation adjusted by purity.