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. 2021 Oct 13;11:759346. doi: 10.3389/fonc.2021.759346

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Copyright © 2021 Lu, Kang, Ling, Pan, Du and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SLC7A11 modulates ferroptosis induced by erastin in NSCLC cells. (A) Determination of the viability in SLC7A11 knockdown A549 cells with erastin (5 µM) treatment for 24 h. The intercellular ROS (B), MDA (C), and Fe²⁺ levels (D) were significantly suppressed abrogated on SLC7A11 knockdown cells. (E) Cell viability of SLC7A11 knockdown Calu-3 cells with erastin (5 µM) treatment for 24 h. The intercellular ROS (F), MDA (G), and Fe²⁺ levels (H) were significantly suppressed abrogated on SLC7A11 knockdown cells. **P < 0.01 and ***P < 0.001.