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. 2021 Oct 13;11:745384. doi: 10.3389/fonc.2021.745384

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Copyright © 2021 Zhou, Han, Li, Pi, Lyu, Xiang, Zhou, Chen, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression of the hub genes in melanoma tissue and normal skin specimens. Using IHC staining, all the hub genes (MLANA, PMEL, EDNRB, MIA, GPR143, SOX10, PRAME, TYR, MITF, and SLC45A2) are expressed at higher levels in the melanoma tissue (n = 25) when compared to normal skin. (A) IHC staining. (B) Quantification of the protein levels of the hub genes in melanoma tissues. IHC: Immunohistochemistry. IHC stain, AEC, original magnification: 100 × (inset, IHC stain, AEC, original magnification: 400 ×).