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. 2021 Oct 13;12:754038. doi: 10.3389/fphar.2021.754038

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Copyright © 2021 Ren, Jin, Hu, Chen, Yang, Wu, Zhou, Sun, Gao, Zhang and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Betulin treatment can inhibit the degradation of extracellular matrix. OA chondrocytes were cultured with betulin (0, 25, 50, and 100 μM) of different concentrations for 2 h, followed by stimulation with or without IL-1β (10 ng/ml) for 24 h. (A–B) The protein expression levels of Collagen II, Aggrecan, MMP13, and ADAMTS-5 were detected by Western blot and quantitatively analyzed. (C–F) Immunofluorescence staining combined with DAPI staining (scale: 25 μm) was used to detect the fluorescent expression of MMP13.The data in the figure are represented as the mean ± SD, **p < 0.01 compared with the control group, ^@@ p < 0.01 compared with the IL-1β group, n = 3.