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. 2021 Oct 13;12:754038. doi: 10.3389/fphar.2021.754038

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Copyright © 2021 Ren, Jin, Hu, Chen, Yang, Wu, Zhou, Sun, Gao, Zhang and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Betulin promotes nuclear translocation of Nrf2 via the AKT signal pathway. The chondrocytes were pretreated with AKT inhibitor MK2206 (10 μM) for 2 h and then treated with betulin (50 μM) for 2 h. (A–D) The protein levels of Nu-Nrf2, Cy-Nrf2, and p-AKT were detected by Western blotting and quantitatively analyzed. The results showed that the AKT signal participated in the inflammatory process induced by IL-1β. The data in the figure show that the average value is ±SD, **p < 0.01 compared with the control group, ^## p < 0.01 compared with the Betulin-treated group, n = 3.