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. 2021 Oct 13;8:725275. doi: 10.3389/fmolb.2021.725275

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Copyright © 2021 Huang, Zhang, Guo, Lu, Wang, Cheng, Dong, Lyu, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic diagram summarized the mechanism of PIEZO1/Ca²⁺ signaling in radiation-induced epithelial-to-mesenchymal transition (EMT) by forming a positive feedback with TGF-β1. Irradiation leads to increased PIEZO1 expression and decreased C/EBPβ expression in rat alveolar type II epithelial (RLE-6TN) cells. Increased expression of PIEZO1 enhanced Ca²⁺ influx, which activates HIF-1α to induce TGF-β1 expression and following EMT. C/EBPβ expression was inhibited by exogenous TGF-β1. C/EBPβ binds to the promoter region of PIEZO1 to inhibit PIEZO1 expression. The PIEZO1/HIF-1α/TGF-β1/C/EBPβ axis constitutes a positive feedback mechanism.